HCID 178496563, compound → HCID 178496562, compound

HRID 1594675

Reaction equation

HRID 1594675 reaction equation
[N+:1]([C:4]1[C:5](=[O:20])[N:6]([CH2:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([O:18][CH3:19])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[C:5](=[O:20])[N:6]([CH2:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([O:18][CH3:19])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[CH3:10]

Participants

4

Reactant 1

HCID 178496563HCID 178496563, compound

Product 1

HCID 178496562HCID 178496562, compoundYield 91.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of cis-3-nitro-1-(4-methoxycyclohexylmethyl)-4-methyl-2-pyridone (0.16 g, 0.57 mmol) and 10% Pd/C (0.06 g) in ethanol was hydrogenated at 50 psi in a Parr apparatus for 22 hours. The catalyst was removed by filtration, and the solvent was evaporated to give cis-3-amino-1-(4-methoxycyclohexylmethyl)-4-methyl-2-pyridone (0.13 g, 0.52 mmol, 91%).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-1f9f8a207409435394372a044b20aa43
Source dataset
uspto-grants-2001_09
Patent number
US06284768B1

Linked notes

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