4-Fluorobenzenesulfonyl chloride → 2-(2-Fluorophenyl)-1-[(4-fluorophenyl)sulfonyl]pyrrolidine

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:12][CH2:11][CH2:10][NH:9]1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chloride

HCID 36133062-(2-fluorophenyl)pyrrolidine

Product 1

HCID 217067142-(2-Fluorophenyl)-1-[(4-fluorophenyl)sulfonyl]pyrrolidine

Procedure

The title compound, white solid, m.p. 108° C. and MS: m/e=324.2 (M+H+) was prepared in accordance with the general method of example 1e from (RS)-2-(2-fluoro-phenyl)-pyrrolidine and 4-fluoro-benzenesulfonyl chloride.

Sources & evidence

ORD record: ord-e3faf9edae35418da786147414e9f18d
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06284785B1

Reaction notes

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