4-Chlorobenzenesulfonyl chloride → HCID 40432134, compound

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:9]2[CH2:10][CH2:11][CH2:12][C@H:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chloride

HCID 7022776(S)-2-(4-Fluorophenyl)pyrrolidine

Product 1

HCID 40432134HCID 40432134, compound

Procedure

The title compound, white solid, m.p. 120° C. and MS: m/e=339 (Me) was prepared in accordance with the general method of example 1e from (S)-2-(4-fluoro-phenyl)-pyrrolidine and 4-chloro-benzenesulfonyl chloride.

Sources & evidence

ORD record: ord-8cc6c83e62384b01904a8808741213e6
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06284785B1

Reaction notes

Loading…