1-Bromo-3-isopropoxybenzene → 2-(Propan-2-yloxy)benzaldehyde

Reaction equation

[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1Br)([CH3:3])[CH3:2].BrC1C=CC=[C:15]([O:19]C(C)C)C=1>>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:15]=[O:19])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 32608011-Bromo-3-isopropoxybenzene

HCID 219254271-Bromo-2-(1-methylethoxy)benzene

Product 1

HCID 2500782-(Propan-2-yloxy)benzaldehydeYield 70%

Procedure

The title compound was prepared as in Example 257A but employing 2-iso-propyloxybromobenzene in lieu of 1-bromo-3-isopropoxybenzene. Purification on silica, gel with 10% ether/hexane afforded the title compound (2.3 g, 70%).

Workup

customThe title compound was prepared as in Example 257A
customPurification on silica, gel with 10% ether/hexane

Sources & evidence

ORD record: ord-2da7e06ccd1c47028a00ce179b1128be
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06284796B1

Reaction notes

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