1-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-ol → 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(2-hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amino]-thiazol-4-one

HRID 159503Notes

Reaction equation

HRID 159503 reaction equation
[CH3:33][NH:34][CH2:35][CH:36]([CH2:37][N:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1)[OH:43].[Cl:1][c:2]1[cH:3][c:4]([C:29]([F:30])([F:31])[F:32])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:26])[NH:19][CH:20]([S:22][CH2:23][CH2:24][CH3:25])[S:21]4)[cH:13][cH:14][c:15]23)[cH:27][cH:28]1>>[Cl:1][c:2]1[cH:3][c:4]([C:29]([F:30])([F:31])[F:32])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:26])[N:19]=[C:20]([N:34]([CH3:33])[CH2:35][CH:36]([CH2:37][N:38]5[CH2:39][CH2:40][CH2:41][CH2:42]5)[OH:43])[S:21]4)[cH:13][cH:14][c:15]23)[cH:27][cH:28]1

Participants

3

Reactant 2

HCID 225620281-(Methylamino)-3-(pyrrolidin-1-yl)propan-2-olHCID 866565305-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one

Product 1

HCID 673456045-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(2-hydroxy-3-pyrrolidin-1-yl-propyl)-methyl-amino]-thiazol-4-one

Sources & evidence

ORD record
ord-2c6d9010e8ca4a03af3600398f43239a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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