4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)pentanoic acid ethyl ester

HRID 1595577

Reaction equation

[CH2:1]([O:3][C:4](=[O:10])[CH:5](Br)[CH2:6][CH2:7][CH3:8])[CH3:2].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([SH:19])=[CH:15][CH:14]=1>>[CH2:1]([O:3][C:4](=[O:10])[CH:5]([S:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 79071Ethyl 2-bromovalerate

Product 1

HCID 545709022-(4-Methoxy-phenylsulfanyl)pentanoic acid ethyl ester

Procedure

2-(4-Methoxy-phenylsulfanyl)-pentanoic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from ethyl2-bromovalerate (8.23 g, 39.3 mmol) and 4-methoxythiophenol (5 g, 35.7 mmol), 10.46 g (100%); clear oil; MS: 269 (M+H)+.

Sources & evidence

ORD record: ord-8161074d5683485eb4dbeed08b587621
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288086B1

Linked notes

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