Bis(2-chloroethyl)ethylamine → 4-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-ethyl-piperidine-4-carboxylic acid ethyl ester

HRID 1595656

Reaction equation

HRID 1595656 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])[CH3:2].[CH2:24]([N:26]([CH2:30][CH2:31]Cl)[CH2:27][CH2:28]Cl)[CH3:25]>>[CH2:1]([O:3][C:4]([C:5]1([S:6]([C:9]2[CH:10]=[CH:11][C:12]([O:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH2:28][CH2:27][N:26]([CH2:30][CH3:31])[CH2:24][CH2:25]1)=[O:23])[CH3:2]

Participants

3

Reactant 2

HCID 10848Bis(2-chloroethyl)ethylamineHCID 11121795HCID 11121795, compound

Product 1

HCID 117621714-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-ethyl-piperidine-4-carboxylic acid ethyl ester

Procedure

4-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-ethyl-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method outlined in example 83 starting from [4-(4-chloro-phenoxy)-benzenesulfonyl]-acetic acid ethyl ester (4 g, 11.3 mmol) and ethyl-bis-(2-chloro-ethyl)-amine (2.32 g, 16.9 mmol). Yield 3.36 g (66%); brown oil; MS: 452.0 (M+H)+

Sources & evidence

ORD record
ord-38e57f5b266a4937b34145bdea9c680f
Source dataset
uspto-grants-2001_09
Patent number
US06288086B1

Linked notes

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