Formaldehyde → Methyl 2-(N-methylenamino)-2-methylbutyrate
Reaction equation
[NH2:1][C:2]([CH3:9])([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4].[CH2:10]=O>CCOCC>[CH2:10]=[N:1][C:2]([CH3:9])([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To methyl 2-amino-2-methylbutyrate (2.62 g) was dropped at room temperature 37% formalin (2.27 g), and the mixture was stirred for 4 h. Then the reaction mixture was dissolved in ether and washed with water. The organic phase was dried over magnesium sulfate, filtered and evaporated to get the captioned compound (2.80 g).
Workup
- washwashed with water
- dry with materialThe organic phase was dried over magnesium sulfate
- filtrationfiltered
- customevaporated
Sources & evidence
- ORD record
- ord-68a473c1f9ff4ba9bb8af051b7713fc6
- Source dataset
- uspto-grants-1999_11
- Patent number
- US05977025
Reaction notes
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