HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1602151Generated: October 26, 2026
Formic Acid → 1,3-Dicyclopropylmethyl xanthine
https://huagongshe.com/reaction/1602151
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Formamide | HCID 713 | — |
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | 6-Amino-1,3-bis(cyclopropylmethyl)uracil | HCID 18624515 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | 1,3-Dicyclopropylmethyl xanthine | HCID 15291303 | — |
Reaction Steps
1,3-Di-cyclopropylmethyl xanthine was prepared using an analogous procedure to that described in Chem. Berichte 88, 1306-1312, 1955: 20.2 g (0.0855 mol) of 1,3-di-cyclopropylmethyl-6-amino-uracil was dissolved in 100 ml of formamide, then 5.9 g sodium nitrite was added and at 60° C. 13.4 ml formic acid was added slowly with stirring. After the colour had changed from yellow to violet, the mixture was heated up to 100° C. and 3.1 g of sodium dithionite (Na2S2O4) was added in small portions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05981535 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-40bb0d42285548b88b7e404452799203 |
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| Source note | uspto-grants-1999_11 |
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