Phenylacetyl chloride → GS 389

HRID 1602170

Reaction equation

[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][O:23]C1C=CC(CC(Cl)=O)=CC=1.C1(CC(Cl)=O)C=CC=CC=1>>[CH3:22][O:23][C:5]1[CH:4]=[CH:3][C:2]([CH2:1][CH:8]2[C:17]3[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=3)[CH2:11][CH2:10][NH:9]2)=[CH:7][CH:6]=1

Participants

Reactant 3

HCID 7679Phenylacetyl chloride

HCID 300241-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

HCID 27346884-Methoxyphenylacetyl chloride

Product 1

HCID 170524GS 389

Procedure

1,2,3,4-Tetrahydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinoline was prepared by a procedure analogous to that described in example 17 for 1,2,3,4-tetrahydro-1-benzyl-6,7-di-methoxyisoquinoline but substituting in the first step (4-methoxyphenyl)acetyl chloride for phenylacetyl chloride.

Sources & evidence

ORD record: ord-8fb7878d5365422c956cfe5e043fa3a3
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05981521

Linked notes

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