N,N-dimethyl-2-nitrobenzamide → 2-Amino-N,N-dimethylbenzamide
Reaction equation
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N+:10]([O-])=O>[Pd].CO>[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Palladium on charcoal (0.54 g, 10% Pd by weight) was added to a solution of 2.1 g N,N-dimethyl-2-nitrobenzamide in 150 mL methanol. The resulting suspension was hydrogenated at room temperature at atmospheric pressure for three hours. After filtration of the catalyst, the solvent was removed in vacuo affording N,N-dimethyl-2-aminobenzamide (1.8 g).
Workup
- filtrationAfter filtration of the catalyst
- customthe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-22b2c6b43ef84da4aab3379d9e193b3c
- Source dataset
- uspto-grants-1999_11
- Patent number
- US05985837
Reaction notes
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