Water → Timolol Maleate

HRID 1603402

Reaction equation

HRID 1603402 reaction equation
[CH3:1][CH2:2][CH:3]([C:5]([OH:7])=[O:6])C.[CH3:8][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:11])[CH3:10].[OH2:29]>C([O-])(=O)C.[Zn+2].C([O-])(=O)C>[CH3:11][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:8])[CH3:10].[CH:3](/[C:5]([OH:7])=[O:6])=[CH:2]/[C:1]([OH:16])=[O:29]

Participants

5

Reactant 3

HCID 962Water2×HCID 83142-Methylbutanoic AcidHCID 33624Timolol

Product 1

HCID 5281056Timolol Maleate

Reagents, catalysts & solvents 1

HCID 11192Zinc AcetateCatalyst

Procedure

15 grams of Carbopol 974P is dispersed in 40 grams of heavy mineral oil USP and is added to 841.5 grams of water containing 2.5 grams of timolol meleate with vigorous stirring. 100 grams of water containing 1.0 gram of zinc acetate is added in a controlled fashion with homogenization to get a particle size distribution size below 5 micron.

Workup

  1. customto get a particle size distribution size below 5 micron

Sources & evidence

ORD record
ord-9cca235f36404870a5655411ed51d3e0
Source dataset
uspto-grants-1999_11
Patent number
US05989535

Linked notes

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