Boron tribromide → Phenol, 4-(2,2-difluorocyclopropyl)-

Reaction equation

[F:1][C:2]1([F:13])[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][C:8]([O:11]C)=[CH:7][CH:6]=1.B(Br)(Br)Br>>[F:1][C:2]1([F:13])[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 21549152HCID 21549152, compound

Product 1

HCID 21549151Phenol, 4-(2,2-difluorocyclopropyl)-

Procedure

p-(2,2-Difluorocyclopropyl)phenol was prepared from 120 g. of p-(2,2-difluorocyclopropyl)anisole and 81 g. of boron tribromide according to the procedure described above in Example 1, part (c), affording 72 g. of oil used directly in the following reaction.

Workup

customaffording 72 g
customof oil used directly in the following reaction

Sources & evidence

ORD record: ord-9760bec5e0814e4fb5ceb31c1e14c843
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03948973

Reaction notes

Loading…