Chloroform → 2-(4-Acetylphenoxy)-2-methylpropionic acid

HRID 1605118Notes

Reaction equation

HRID 1605118 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-:11].[Na+].C(Cl)(Cl)Cl>CC(C)=O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([O:1][C:5]([CH3:6])([CH3:4])[C:8]([OH:10])=[O:11])=[CH:3][CH:4]=1)(=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 74694'-HydroxyacetophenoneHCID 14798Sodium Hydroxide

Product 1

HCID 1041062-(4-Acetylphenoxy)-2-methylpropionic acid

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g. of p-hydroxyacetophenone, 960 g. of sodium hydroxide and 715 g. of chloroform in 11 liters of acetone according to the procedure described above in Example 1, part (d). The product was recrystallized from carbon tetrachloride and from isopropyl acetate to give 2-(p-acetylphenoxy)-2-methylpropionic acid as a pale cream solid, m.p. 108°-110°C.

Workup

  1. custom2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g
  2. customThe product was recrystallized from carbon tetrachloride and from isopropyl acetate

Sources & evidence

ORD record
ord-43972321ca904c3ca0b13546863795ca
Source dataset
uspto-grants-1976_04
Patent number
US03948973

Reaction notes

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