Dicyclohexylcarbodiimide → N-(1-Methylcyclobutyloxycarbonyl)-Aspartic Anhydride
Reaction equation
[CH3:1][C:2]1([O:6][C:7]([NH:9][C@H:10]([C:15]([OH:17])=[O:16])[CH2:11][C:12]([OH:14])=O)=[O:8])[CH2:5][CH2:4][CH2:3]1.C1(N=C=NC2CCCCC2)CCCCC1>O1CCOCC1>[CH3:1][C:2]1([O:6][C:7]([NH:9][C@@H:10]2[C:15](=[O:16])[O:17][C:12](=[O:14])[CH2:11]2)=[O:8])[CH2:3][CH2:4][CH2:5]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
A solution of 2.45 g. of N-(1-methylcyclobutyloxycarbonyl)-aspartic acid in 50 ml. of dioxane is prepared and 2.2 g. of dicyclohexylcarbodiimide is added with vigorous stirring. After stirring at 25°C. for 2 hours, the dicyclohexylurea is removed by filtration and the dioxane removed by evaporation in vacuo. The resulting solid is substantially pure N-(1-methylcyclobutyloxycarbonyl)-aspartic anhydride.