Methyl iodide → 3-Methoxy-5-(trifluoromethyl)benzoic acid
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:15]I.C[O-].[Na+]>CO>[CH3:15][O:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[C:5]([OH:7])=[O:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
This product is prepared according to the procedure of Example 5 and comprises contacting 3-hydroxy-5-trifluoromethylbenzoic acid with methyl iodide in methanol containing sodium methoxide as the base, m.p. 131°-135° C.
Workup
- customThis product is prepared
Sources & evidence
- ORD record
- ord-b92fa04e02ba4fd087351bc967c99679
- Source dataset
- uspto-grants-1976_04
- Patent number
- US03953595
Reaction notes
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