Benzene → 1-Aminotetralin, (R)-

Reaction equation

[C:1]([NH:9][C@H](C(O)=O)CCC(O)=O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:19]1[CH:24]=CC=C[CH:20]=1>>[C@H:1]1([NH2:9])[C:2]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:24][CH2:19][CH2:20]1

Participants

Reactant 2

HCID 241Benzene

HCID 11345724N-Benzoyl-L-glutamic acid

Product 1

HCID 70580721-Aminotetralin, (R)-

Procedure

The (R) amine is made in the same way as described in Example 8, but from the salt from N-benzoyl-(S)-glutamic acid. It has [α]D25 -54.0° (c 5.1, benzene).

Sources & evidence

ORD record: ord-b2b3e593e34e4306ade838d036c22bcf
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03953606

Reaction notes

Loading…