Isobutylamine → HCID 19851815, compound
Reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)C=CC=CC=1.[CH2:36]([NH2:40])[CH:37]([CH3:39])[CH3:38]>>[CH2:36]([NH:40][C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:14])[CH:37]([CH3:39])[CH3:38]Participants
3
Procedure
N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and isobutylamine (185 μl) were subjected to similar reactions to those described in References 2 and 4 to give 2-isobutylaminocarbonylthioethylamine (crude formate: 256 mg) which was then dissolved in anhydrous methanol (5 ml). Triethylamine (376 μl) and mitomycin A (151 mg: 0.8 molar equivalent) were added to the solution. The reaction solution was treated in a similar manner to that described in Example 1 to obtain Compound 24 (71 mg) in the form of grayish blue powders with a yield of 33%.
Sources & evidence
- ORD record
- ord-dffa9e2511cc45d28bd7bb6c2010ef62
- Source dataset
- uspto-grants-1989_09