Morpholine → 4-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

HRID 16074

Reaction equation

HRID 16074 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15](Cl)(=[O:17])=[O:16])=[C:10]([F:19])[CH:9]=1>ClCCl>[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:16])=[O:17])=[C:10]([F:19])[CH:9]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

Product 1

HCID 686063584-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Morpholine (0.16 ml) was added to a stirred solution of 4-bromo-2,5-difluoro-benzenesulfonyl chloride (0.18 g) in dichloromethane (6 ml) under nitrogen. The reaction mixture was stirred overnight and then quenched with water. The organic phase was dried (MgSO4) and concentrated in vacuo to give the sub-title compound as a white solid (200 mg).

Workup

  1. customquenched with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-39a68fdc2cf342168e2bccff054cfd0b
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Linked notes

Loading…