n-((4-Benzylmorpholin-2-yl)methyl)acetamide → N-(morpholin-2-ylmethyl)acetamide
Reaction equation
[C:1]([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7]1)(=[O:3])[CH3:2]>C(O)C.C(O)(=O)C.[Pd]>[C:1]([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][NH:8][CH2:7]1)(=[O:3])[CH3:2]Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
2-Acetylaminomethyl-4-benzylmorpholine (120 g) is dissolved in a mixture of ethanol (1000 ml) and acetic acid (30 ml) and hydrogenated over 10% palladium on carbon (5 g) at about 60° C. After the calculated amount of the hydrogen is absorbed, the catalyst is filtered off. The filtrate is evaporated under reduced pressure to give the title compound as an oil.
Workup
- customAfter the calculated amount of the hydrogen is absorbed
- filtrationthe catalyst is filtered off
- customThe filtrate is evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-aed908b8f1af456baaf178f72a08fb01
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04870074
Reaction notes
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