5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 1608636Notes

Reaction equation

HRID 1608636 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

Product 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridineYield 99.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

After a suspension of 5-[2(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Workup

  1. washwas washed with 3N sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationThen, the solvent was distilled off

Sources & evidence

ORD record
ord-74624a2a1b5b49229391bdcce7eb0e9a
Source dataset
uspto-grants-1995_03
Patent number
US05395839

Reaction notes

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