Ethanol → 2-(2-Tert-butoxycarbonylamino-pyridin4-ylmethyl)-malonic acid monoethyl ester

HRID 160902

Reaction equation

HRID 160902 reaction equation
[CH2:32]([Cl:33])[Cl:34].[CH2:3]([CH3:4])[O:5][C:6]([CH:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:13][c:14]1[cH:15][c:16]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[n:17][cH:18][cH:19]1)=[O:28].[CH3:29][CH2:30][OH:31].[K+:2].[OH-:1]>>[CH2:3]([CH3:4])[O:5][C:6]([CH:7]([C:8](=[O:9])[OH:10])[CH2:13][c:14]1[cH:15][c:16]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[n:17][cH:18][cH:19]1)=[O:28]

Participants

6

Reactant 5

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 6344DichloromethaneHCID 545579702-(2-Tert-butoxycarbonylamino-pyridin4-ylmethyl)-malonic acid diethyl ester

Product 1

HCID 545486422-(2-Tert-butoxycarbonylamino-pyridin4-ylmethyl)-malonic acid monoethyl ester

Sources & evidence

ORD record
ord-29008402b33b4b4784f1f0e709ea1fce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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