Benzoyl chloride → HCID 261393, compound

Reaction equation

[CH3:1][C:2]([C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:11])=[O:3].[C:12](Cl)(=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([C:12]2[O:11][C:5]3[CH:6]=[CH:7][CH:8]=[C:9]([F:10])[C:4]=3[C:2](=[O:3])[CH:1]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 27373242'-Fluoro-6'-hydroxyacetophenone

Product 1

HCID 261393HCID 261393, compound

Procedure

4 is prepared from 2-fluoro-6-hydroxyacetophenone (see Example 6) and benzoyl chloride by the procedure of Example 1. The material is purified by flash chromatography (eluting with 25% ethyl acetate in hexane), yielding 4 with a melting point of 144°-145° C.

Workup

customThe material is purified by flash chromatography (eluting with 25% ethyl acetate in hexane)
customyielding 4 with a melting point of 144°-145° C.

Sources & evidence

ORD record: ord-73d806d333a54d9ba4ba5a546355d491
Source dataset: uspto-grants-1995_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05399584

Reaction notes

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