Acetyl chloride → 1-(2,4-Dimethoxyphenyl)ethanone

HRID 1609451

Reaction equation

HRID 1609451 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:11](=[O:13])[CH3:12]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 90251,3-DimethoxybenzeneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 700161-(2,4-Dimethoxyphenyl)ethanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using a Perrier modification, Perrier, Chem. Ber., Vol. 33, pp. 819 et seq. (1900), and Perrier, Bull. Soc. Chim. France, pp. 859 et seq. (1904), 1,3-dimethoxybenzene (138.0 g) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) is reacted with acetyl chloride (72.0 g), methylene chloride (500 ml), and aluminum chloride (145 0 g) to provide 2',4'-dimethoxy-acetophenone, which may then be purified using standard vacuum fractional distillation.

Sources & evidence

ORD record
ord-f142c111c1a443f89dce2f95e78eae4c
Source dataset
uspto-grants-1995_03
Patent number
US05401720

Linked notes

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