[[5-Chloro-3'-fluoro-4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-2-yl]oxy]-acetic acid → (2S)-2-[[3'-fluoro-4'-(1-pyrrolidinylcarbonyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid
Reaction equation
ClC1C=CC(OCC(O)=O)=C([C:8]2[CH:13]=[CH:12][C:11]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:15])=[C:10]([F:21])[CH:9]=2)C=1.B([C:30]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:31]=1[O:32][C@@H:33]([CH3:37])[C:34]([OH:36])=[O:35])(O)O>>[F:21][C:10]1[CH:9]=[C:8]([C:30]2[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:31]=2[O:32][C@@H:33]([CH3:37])[C:34]([OH:36])=[O:35])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:15]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared using the product of example 24 part a) and (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid [WO2004089885] by the method of example 32 step b).
Sources & evidence
- ORD record