(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

HRID 16112

Reaction equation

HRID 16112 reaction equation
[CH3:1][C:2]([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18](C(F)(F)F)[CH:17]=[CH:16][C:15]=2[O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[CH:10][C:9]=1[F:30])=[O:7])([CH3:4])[CH3:3].B(C1C=C([Cl:46])C=CC=1O[C@@H](C)C(O)=O)(O)O>>[Cl:46][C:18]1[CH:17]=[CH:16][C:15]([O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([NH:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])=[C:9]([F:30])[CH:10]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 11539174(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

Product 1

HCID 11538441(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

Procedure

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

Sources & evidence

ORD record
ord-dff6b5a0db1547c19bd0363b932ca948
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Linked notes

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