2,6-Dichloropyrazine → 6-chloro-N-methyl-N-[(1S)-1-phenylethyl]pyrazin-2-amine

HRID 16136

Reaction equation

HRID 16136 reaction equation
[CH3:1][NH:2][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:4].Cl[C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1>>[Cl:18][C:14]1[N:13]=[C:12]([N:2]([CH3:1])[C@H:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:4])[CH:17]=[N:16][CH:15]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 2060073(S)-(-)-N,alpha-Dimethylbenzylamine

Product 1

HCID 588699216-chloro-N-methyl-N-[(1S)-1-phenylethyl]pyrazin-2-amineYield 39%

Procedure

In an analogous fashion to example 1, N-methyl-N-[(1S)-1-phenylethyl]amine (0.27 g, 2.0 mmol) was condensed with 2,6-dichloropyrazine (0.36 g, 2.4 mmol), to furnish the desired product as a light brown solid (192 mg, 39%).

Sources & evidence

ORD record
ord-863f27e57344459eacf6de47048dfb92
Source dataset
uspto-grants-2010_06
Patent number
US07737143B2

Linked notes

Loading…