1-Acetylpiperidine-4-carbonitrile → 4-(4-Trifluoromethylbenzoyl)piperidine

HRID 1614618Notes

Reaction equation

HRID 1614618 reaction equation
C(N1CCC(C#N)CC1)(=O)C.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:19]=[CH:18][C:17]([Mg]Br)=[CH:16][CH:15]=1.FC(F)(F)C1C=C(C=CC=1)[C:29]([CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)=[O:30]>>[F:12][C:13]([F:23])([F:22])[C:14]1[CH:19]=[CH:18][C:17]([C:29]([CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[O:30])=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 27562861-Acetylpiperidine-4-carbonitrileHCID 50864474-(3-Trifluoromethylbenzoyl)piperidineHCID 178506198HCID 178506198, compound

Product 1

HCID 116374554-(4-Trifluoromethylbenzoyl)piperidine

Procedure

The title compound is prepared from 1-acetyl-4-cyanopiperidine and 4-trifluoromethylphenylmagnesium bromide according to the procedure given for 4-(3-trifluoromethylbenzoyl)piperidine in J. Med. Chem. 13, 1-6 (1970).

Sources & evidence

ORD record
ord-756c542c905e46459da19279a79c87ed
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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