Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86660998, compound

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[CH3:20])[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.Cl.[CH3:22][NH:23][O:24][CH3:25]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[CH3:20])[CH2:9][C:10]([N:23]([O:24][CH3:25])[CH3:22])=[O:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)

HCID 66666388HCID 66666388, compound

Product 1

HCID 86660998HCID 86660998, compound

Procedure

In analogy to example 74, step 4, from 3-(4-bromophenyl)-3-(4-chloro-2-methylphenyl)-propanoic acid and N,O-dimethylhydroxylamine hydrochloride was prepared the title compound as a colorless oil, MS (ESI+): m/z=398.03 [M+H]+.

Sources & evidence

ORD record: ord-40dd9d154d6e400ab023f407bbb5b013
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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