1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate → HCID 67257898, compound
Reaction equation
[CH3:1][N:2]([CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])C.[Br:14][C:15]1[CH:20]=C[N:18]=[C:17](N)[CH:16]=1>CC(O)=O.O>[Br:14][C:15]1[CH:16]=[CH:17][N:18]=[C:1]([NH:2][CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])[CH:20]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of dimethyl 2-((dimethylamino)methylene)malonate (11.5 g, 65 mmol, 2.2 equiv) and 4-bromopyridin-2-amine (5 g, 28.9 mmol, 1 equiv) in AcOH (40 mL) was stirred at room temperature for 24 h. Then the reaction mixture was diluted with water, filtered, the filter cake was dried to give 4.8 g of the desired product. MS (ESI): 315, 317 (MH+).