((4-Methoxyphenyl)methyl)hydrazine → 3-(4-Methoxy-benzyl)-3,4-diaza-bicyclo[4.1.0]heptan-2,5-dione
Reaction equation
[CH:1]12[C:7](=[O:8])[O:6][C:4](=O)[CH:2]1[CH2:3]2.[CH3:9][O:10][C:11]1[CH:19]=[CH:18][C:14]([CH2:15][NH:16][NH2:17])=[CH:13][CH:12]=1>C(#N)C>[CH3:9][O:10][C:11]1[CH:19]=[CH:18][C:14]([CH2:15][N:16]2[NH:17][C:4](=[O:6])[CH:2]3[CH:1]([CH2:3]3)[C:7]2=[O:8])=[CH:13][CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.0 g (8.92 mmol) 1,2-cyclopropanedicarboxylic acid anhydride is dissolved in 5 ml acetonitrile, 1.5 g (9.86 mmol) 4-methoxy-benzyl-hydrazine dissolved in 5 ml acetonitrile are added dropwise and the mixture is refluxed overnight. During cooling to RT a precipitate is formed, which is filtered off, washed with acetonitrile and dried in the vacuum dryer at 50° C.