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5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one → 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-2H-pyridazin-3-one

HRID 1620017
Notes
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Reaction equation

HRID 1620017 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH2:3]1>[O-2].[Mn+4].[O-2].O1CCOCC1>[CH3:1][C:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH:3]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 1

HCID 674612285-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one

Product 1

HCID 674623945-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-2H-pyridazin-3-one

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

100 mg (321 μmol) 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one, 0.08 mg (964 μmol) activated manganese(IV)oxide and 10 ml dioxane are combined and stirred overnight at 120° C. The reaction mixture is filtered through Celite, washed with DCM and EA and the solv. of the filtrate is eliminated i.V. The residue is recrystallised with DMF.

Workup

  1. filtrationThe reaction mixture is filtered through Celite
  2. washwashed with DCM and EA
  3. customThe residue is recrystallised with DMF

Sources & evidence

ORD record
ord-cc012d534f784aa091530b9e63683dbe
Source dataset
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08772323B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes