N,N-Diethylethylenediamine → HCID 178464053, compound
Reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[CH2:8]([N:10]([CH2:14][CH3:15])[CH2:11][CH2:12][NH2:13])[CH3:9]>CO>[CH2:8]([N:10]([CH2:14][CH3:15])[CH2:11][CH2:12][NH:13][C:2]1[CH2:6][S:5][C:4](=[O:7])[N:3]=1)[CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 4-thioxo-1,3-thiazolidin-2-one (5.32 g) in methanol (200 mL) was added N,N-diethylethane-1,2-diamine (6.17 mL). The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (5.44 g).
Workup
- customthe solvent was evaporated under reduced pressure
- customThe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
Sources & evidence
- ORD record
- ord-643f229b7a2c4b8ea85defa188b7b6d0
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
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