Hydrogen chloride-ethyl acetate → HCID 178456897, compound

HRID 1620499

Reaction equation

HRID 1620499 reaction equation
[O:1]=[C:2]1[N:6]=[C:5]([NH:7][CH2:8][C:9]#[CH:10])/[C:4](=[CH:11]/[CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)/[S:3]1.[ClH:25].C(OCC)(=O)C>>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12](/[CH:11]=[C:4]2/[C:5]([NH:7][CH2:8][C:9]#[CH:10])=[N:6][C:2](=[O:1])[S:3]/2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178456946HCID 178456946, compound

Product 1

HCID 178456897HCID 178456897, compound

Procedure

A mixed solution of tert-butyl 4-{(Z)-[2-oxo-4-(prop-2-yn-1-ylamino)-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (14.0 g) and 4M hydrogen chloride/ethyl acetate solution (80 mL) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-70343f03bc6e4b52a2f38fb43b3958f6
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Linked notes

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