4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178521297, compound
Reaction equation
[CH:1]1([NH:4][C:5](=[O:8])[CH2:6][NH2:7])[CH2:3][CH2:2]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[CH:1]1([NH:4][C:5](=[O:8])[CH2:6][NH:7][C:10]2[CH2:14][S:13][C:12](=[O:15])[N:11]=2)[CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of N-cyclopropylglycinamide (1.22 g) (J. Med. Chem. 2005, 48, 7808-7820) in ethanol (12 mL) was added 4-thioxo-1,3-thiazolidin-2-one (1.42 g), and the mixture was stirred at room temperature for 5 hr. The precipitate was collected by filtration, and the solid was washed with ethanol to give the title compound (2.0 g).
Workup
- filtrationThe precipitate was collected by filtration
- washthe solid was washed with ethanol
Sources & evidence
- ORD record
- ord-0b8204a8043e4a2d837411209ea78c16
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
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