4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518110, compound
Reaction equation
[NH2:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[OH:8][CH2:7][C:3]1([CH2:2][NH:1][C:10]2[CH2:14][S:13][C:12](=[O:15])[N:11]=2)[CH2:6][CH2:5][CH2:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of [1-(aminomethyl)cyclobutyl]methanol (1.00 g) in ethanol (30 mL) was added 4-thioxo-1,3-thiazolidin-2-one (1.16 g), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the obtained powder was washed with ethyl acetate to give the title compound (795 mg).
Workup
- temperaturethe mixture was heated
- temperatureunder reflux overnight
- concentrationThe reaction mixture was concentrated under reduced pressure
- washthe obtained powder was washed with ethyl acetate
Sources & evidence
- ORD record
- ord-09509325a6e44c5f96c0792b469854ab
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
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