HCID 86678926, compound → HCID 86678927, compound
Reaction equation
C(OC(=O)[NH:10][C@@H:11]([C:17]1([OH:20])[CH2:19][CH2:18]1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][C@@H:11]([C:17]1([OH:20])[CH2:19][CH2:18]1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of benzyl[(1S)-2-(dimethylamino)-1-(1-hydroxycyclopropyl)-2-oxoethyl]carbamate (190 mg) in ethanol (5 mL) was added 10% palladium carbon (69 mg) at room temperature. The reaction mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (60 mg).
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-a6aec1674a4342679378c216bd8f6d11
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
Loading…