Cyclohexaneacetic acid, methyl ester → 6-(Cyclohexylmethyl)-1-(1-ethylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

HRID 16235

Reaction equation

HRID 16235 reaction equation
[NH2:1][C:2]1[N:6]([CH:7]([CH2:10][CH3:11])[CH2:8][CH3:9])[N:5]=[CH:4][C:3]=1[C:12]([NH2:14])=[O:13].[CH:15]1([CH2:21][C:22](OC)=O)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([CH2:21][C:22]2[NH:14][C:12](=[O:13])[C:3]3[CH:4]=[N:5][N:6]([CH:7]([CH2:10][CH3:11])[CH2:8][CH3:9])[C:2]=3[N:1]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 139743Cyclohexaneacetic acid, methyl esterHCID 179603685-Amino-1-(pentan-3-yl)-1H-pyrazole-4-carboxamide

Product 1

HCID 1354229306-(Cyclohexylmethyl)-1-(1-ethylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Procedure

The product is obtained in analogy to Example 1/stage 1c) starting from 200 mg (1.02 mmol) of 5-amino-1-(1-ethylpropyl)-1H-pyrazole-4-carboxamide and 482 mg (3.06 mmol) of methyl cyclohexylacetate.

Sources & evidence

ORD record
ord-e8fd0ba11fc94686bec79b801da90577
Source dataset
uspto-grants-2010_06
Patent number
US07737156B2

Linked notes

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