Pyridine → N-(2-hydroxy-4-methoxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

HRID 162445Notes

Reaction equation

HRID 162445 reaction equation
[Br:11][c:12]1[s:13][c:14]([CH3:15])[cH:16][c:17]1[C:18]([OH:19])=[O:20].[Br:1][c:2]1[s:3][c:4]([CH3:10])[cH:5][c:6]1[C:7](=[O:8])[Cl:9].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[NH2:25][c:26]1[c:27]([OH:34])[cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]1.[S:21]([Cl:22])([Cl:23])=[O:24].[cH:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1>>[Br:1][c:2]1[s:3][c:4]([CH3:10])[cH:5][c:6]1[C:7](=[O:8])[NH:25][c:26]1[c:27]([OH:34])[cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]1

Participants

7

Reactant 6

HCID 1049PyridineHCID 1140TolueneHCID 24386Thionyl ChlorideHCID 99421632-Amino-5-methoxyphenolHCID 111175892-Bromo-5-methylthiophene-3-carboxylic acidHCID 184222542-Bromo-5-methyl-3-thiophenecarbonyl chloride

Product 1

HCID 10860794N-(2-hydroxy-4-methoxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

Sources & evidence

ORD record
ord-f7b5bf5c0f564e35a54f1daf6938cd96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…