4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide → 1-(4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazol-3-yl)ethanone

Reaction equation

CON(C)[C:4]([C:6]1[C:10]([Cl:11])=[CH:9][N:8]([CH2:12][CH:13]([F:15])[F:14])[N:7]=1)=[O:5].[CH3:17][Mg]Br>>[Cl:11][C:10]1[C:6]([C:4](=[O:5])[CH3:17])=[N:7][N:8]([CH2:12][CH:13]([F:15])[F:14])[CH:9]=1

Participants

Reactant 2

HCID 866737314-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide

HCID 178418573HCID 178418573, compound

Product 1

HCID 710086591-(4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazol-3-yl)ethanoneYield 66%

Procedure

In a manner analogous to that described in Example 14 b), the Grignard reaction of 4-chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide with methylmagnesium bromide yielded the title compound (66% yield) as a colorless oil. MS (ISP): m/z=209.0 [M+H]+.

Sources & evidence

ORD record: ord-e8e9545f6cb5421888d16489d0930898
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785436B2

Reaction notes

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