Ethanolamine → HCID 66678959, compound

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]([NH:20][CH2:21][CH2:22]F)=[O:19])[CH:5]=[CH:6][C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1.C(CN)[OH:25]>>[F:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]([NH:20][CH2:21][CH2:22][OH:25])=[O:19])[CH:5]=[CH:6][C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 86663172N-(2-Fluoroethyl)-N′-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea2×

Product 1

HCID 66678959HCID 66678959, compound

Procedure

Method as described for 1-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-fluoroethyl)urea (intermediate 31) using ethanolamine as starting material.

Sources & evidence

ORD record: ord-f753eddf3ccd452b85bde4aae95e8fba
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785457B2

Reaction notes

Loading…