Ethyl 1-aminocyclohexane-1-carboxylate hydrochloride → HCID 57672866, compound

HRID 1627458Notes

Reaction equation

HRID 1627458 reaction equation
Cl.[CH2:2]([O:4][C:5]([C:7]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:6])[CH3:3].Cl.[CH2:15]([N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)[CH2:16][CH3:17]>>[CH2:2]([O:4][C:5]([C:7]1([NH:13][C:28]([C:27]2[CH:26]=[CH:25][C:24]([N:21]3[CH2:20][CH2:19][N:18]([CH2:15][CH2:16][CH3:17])[CH2:23][CH2:22]3)=[CH:32][CH:31]=2)=[O:29])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:6])[CH3:3]

Participants

3

Reactant 2

HCID 11241228Ethyl 1-aminocyclohexane-1-carboxylate hydrochlorideHCID 67181841HCID 67181841, compound

Product 1

HCID 57672866HCID 57672866, compoundYield 65%

Procedure

741 mg (3.57 mmol) of 1-aminocyclohexanecarboxylic acid ethyl ester hydrochloride was used instead of 1-aminocyclohexanecarboxylic acid methyl ester hydrochloride and 1.00 g (3.57 mmol) of 4-(4-propylpiperazin-1-yl)benzoic acid hydrochloride was used instead of 3-furancarboxylic acid in the process according to Reference Example 15 to obtain 928 mg (65%) of the title compound.

Sources & evidence

ORD record
ord-c24e7d78c1ec40478488a80097ab03d2
Source dataset
uspto-grants-2014_07
Patent number
US08785631B2

Reaction notes

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