HCID 86664828, compound → HCID 67497326, compound

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:15][C:16]1NN=C(C2C=CN=C(NC)C=2)C=1>>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:16])[CH:7]=2)[CH:12]=1

Participants

Reactant 2

HCID 86664828HCID 86664828, compound

HCID 178482070HCID 178482070, compound

Product 1

HCID 67497326HCID 67497326, compoundYield 79%

Procedure

This title intermediate was prepared starting from 23.A (2.10 g, 10.0 mmol) according the procedure described above for conversion of 18.0 to 18.D. The crude product was purified by flash chromatography using 0-10% MeOH/CH2Cl2 for elution to provide 23.B as white solid (1.61 g, 79%).

Workup

customThe crude product was purified by flash chromatography
washfor elution

Sources & evidence

ORD record: ord-71db85fd8d334e30b56879e7f0db2253
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785468B2

Reaction notes

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