HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1632Generated: October 26, 2026
2-Naphthalenesulfonic acid → 4-Fluoro-2-(oxazolin-2-yl)isoindoline
https://huagongshe.com/reaction/1632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Naphthalenesulfonic acid | HCID 8420 | — |
| Reactant | 2-Ethoxy-4,5-dihydro-1,3-oxazole | HCID 12730640 | — |
| Reactant | 4-fluoro-2,3-dihydro-1H-isoindole | HCID 14795867 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Fluoro-2-(oxazolin-2-yl)isoindoline | HCID 19691978 | — |
Reaction Steps
A mixture of 4-fluoroisoindoline (400 mg), 2-ethoxy-2-oxazoline (400 mg), and β-naphthylsulfonic acid (30 mg) in 50 ml of toluene was stirred at 100° C. for 1 hour. The solvent as removed under reduced pressure, and the residue chromatographed on silica gel, eluting with 1-4% methanol in ethyl acetate, to give 4-fluoro-2-(oxazolin-2-yl)isoindoline, a compound of Formula (IB), m.p. 125°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05726197 |
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| Source dataset | uspto-grants-1998_03 |
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| ORD ID | ord-0aed4da618f94372b6ebcb5dce352131 |
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| Source note | uspto-grants-1998_03 |
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