Sodium Cyanide → HCID 20148849, compound
Reaction equation
[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH:4]([CH2:8]OS(C2C=CC(C)=CC=2)(=O)=O)[CH:3]1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[C-:26]#[N:27].[Na+]>CS(C)=O>[C:26]([CH2:8][CH:4]1[CH2:5][C:6](=[O:7])[N:2]([CH3:1])[CH:3]1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)#[N:27]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To 42 g. of 1-methyl-2-phenyl-3-tosyloxymethyl-pyrrolidin-5-one in 72.5 ml. of dimethylsulfoxide was slowly added 5.7 g of sodium cyanide at 45° C. The reaction was stirred for 3 hours at 100° C. and then set at ambient temperature for 18 hours. After decanting into 1500 ml. of ice water, the product was extracted with 2:1 chloroform-ether, dried (Na2SO4) filtered, and concentrated in vacuo to provide 19.0 g. of light yellow crystals.