Ammonia → HCID 178510518, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[CH:17][N:18](C)C)[C:9]2=[O:21])[CH:5]=[CH:6][CH:7]=1.N>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[CH:17][NH2:18])[C:9]2=[O:21])[CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Title product of Example A3 (0.3 g, 1 mmole) was stirred with 10 ml of ethanol for 3 minutes and the mixture then perfused with NH3 for 1 hour at 25°, stirred an additional 16 hours, and concentrated to an oil, which crystallized on standing in vacuo. Trituration with pentane gave purified title product, 0.25 g, m.p. 141°-143°.
Workup
- concentrationconcentrated to an oil, which
- customcrystallized
- customTrituration with pentane gave
- custompurified title product, 0.25 g, m.p. 141°-143°
Sources & evidence
- ORD record
- ord-3df1f2f2226f4197ac868572d8e0119d
- Source dataset
- uspto-grants-1984_10
- Patent number
- US04476307
Reaction notes
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