2,4-Difluorophenylboronic acid → (2',4'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 1635145

Reaction equation

HRID 1635145 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1B(O)O>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:23]2[CH:22]=[CH:21][C:20]([F:19])=[CH:25][C:24]=2[F:26])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

Product 1

HCID 69592801(2',4'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Procedure

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) and 2,4-difluorobenzene boronic acid according to the general procedure B. Obtained as a yellow solid (3.26 g).

Sources & evidence

ORD record
ord-2608648fa7f8435a9920c919acc46d10
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Linked notes

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