Ethyl chloroformate → HCID 67582718, compound
Reaction equation
[CH3:1][C:2]1[CH2:3][C:4](=[O:14])[N:5]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)[N:6]=1.[CH2:15]([O:17][C:18](Cl)=[O:19])[CH3:16]>>[CH2:15]([O:17][C:18](=[O:19])[NH:13][C:10]1[CH:11]=[CH:12][C:7]([N:5]2[C:4](=[O:14])[CH2:3][C:2]([CH3:1])=[N:6]2)=[CH:8][CH:9]=1)[CH3:16]Participants
3
Procedure
From the reaction of 5-methyl-2-(4-aminophenyl)-2,4-dihydro-pyrazol-3-one and ethylchloroformate (per the reaction in Example 11) yields N-(4-(4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-phenyl-carbamic acid ethyl ester. Subsequent reaction with 2-methoxyaniline yields N-(4-(4,5-dihydro-4-(2-methoxyanilinomethylene)-3-methyl-5-oxo-1H-pyrazol-1-yl)-phenyl)-carbamic acid ethyl ester, Mp: 212° C.
Workup
- customper the reaction in Example 11)
Sources & evidence
- ORD record
- ord-6db35c89f627472ca55d8c443bcfe731