HCID 18799766, compound → HCID 18799934, compound

Reaction equation

[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([CH:14]=[O:15])[CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:16][Mg]Br>>[OH:15][CH:14]([C:10]1[CH:9]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[CH:13]=[CH:12][N:11]=1)[CH3:16]

Participants

Reactant 2

HCID 18799766HCID 18799766, compound

HCID 178418573HCID 178418573, compound

Product 1

HCID 18799934HCID 18799934, compoundYield 94.5%

Procedure

Grignard reaction between 4-(4-morpholinyl)methyl-2-pyridine carboxaldehyde (1.03 g, 5.00 mmol) and methylmagnesium bromide (2.50 ml, 7.50 mmol, 1.5 equiv., 3.0 M in ether) yielded 1.05 g (94%) of 2-(1-hydroxyethyl)-4-(4-morpholinyl)methylpyridine.

Sources & evidence

ORD record: ord-be44e1cea32b4fdebbc74a190053f418
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043248

Reaction notes

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