Methyl iodide → 1-methyl-4-(4-nitrophenyl)-1H-imidazole
Reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][NH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[K].[CH3:16]C(C)([O-])C.CI>CS(C)=O>[CH3:16][N:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[N:11]=[CH:12]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared by reacting 4-(4-nitro-phenyl)-imidazole in DMSO with potassium-tert.butoxide at 0° C. and then with methyliodide at 20-25° C.
Workup
- customPrepared
- customat 0° C.
- customat 20-25° C.
Sources & evidence
- ORD record
- ord-d0f1bbea951146c8a5e26bb695dd3931
- Source dataset
- uspto-grants-2000_03
- Patent number
- US06043254
Reaction notes
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